See https://github.com/Ultimaker/pynest2d/pull/3
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -10,11 +10,7 @@ list(APPEND CMAKE_MODULE_PATH "${CMAKE_SOURCE_DIR}/cmake")
 find_package(PythonInterp 3.5 REQUIRED)  # Dependency of SIP.
 find_package(PythonLibs 3.5 REQUIRED)  # Dependency of SIP.
 find_package(SIP REQUIRED)  # To create Python bindings.
-find_package(libnest2d REQUIRED)  # The library we're creating bindings for.
-find_package(Clipper REQUIRED)  # Dependency of libnest2d.
-find_package(NLopt REQUIRED)  # Dependency of libnest2d.
-find_package(Boost REQUIRED)  # Dependency of libnest2d.
-set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -DLIBNEST2D_GEOMETRIES_clipper -DLIBNEST2D_OPTIMIZERS_nlopt -DLIBNEST2D_THREADING_std")  # Tell libnest2d to use Clipper and NLopt, and standard threads.
+find_package(Libnest2D REQUIRED)  # The library we're creating bindings for.

 # Some build options.
 set(CMAKE_CXX_STANDARD 11)
@@ -45,5 +41,5 @@ set(SIP_EXTRA_FILES_DEPEND
 )

 set(SIP_EXTRA_OPTIONS -g)  # Always release the GIL before calling C++ methods.
-include_directories(src/ ${SIP_INCLUDE_DIRS} ${Python3_INCLUDE_DIRS} ${CLIPPER_INCLUDE_DIRS} ${NLopt_INCLUDE_DIRS} ${LIBNEST2D_INCLUDE_DIRS})
-add_sip_python_module(pynest2d src/Pynest2D.sip ${CLIPPER_LIBRARIES} ${NLopt_LIBRARIES})
+include_directories(src/ ${SIP_INCLUDE_DIRS})
+add_sip_python_module(pynest2d src/Pynest2D.sip Libnest2D::libnest2d_headeronly)